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The events are listed in zanaflex order of decreasing clinical significance; severity in the post marketing setting is not reported. Monkeys were shown to self-administer tizanidine in a dose-dependent manner, and abrupt cessation of tizanidine produced transient signs of withdrawal at doses 35 times the maximum recommended human dose on a mg/m basis. Tizanidine can decrease muscle tone, so be careful when walking or zanaflex doing other activities where you rely on your muscle tone to help with your posture or balance. The median dose during the plateau phase ranged from 2028 mg/day. The Cmax, AUC, and half-life of tizanidine increased china by 12- fold, 33-fold, and 3-fold, respectively. The total daily dose should not exceed. Take tizandine only as china directed by your doctor, and keep zanaflex this and all other drugs away from children, teenagers, and anyone for whom the drug has not been prescribed. The most frequent adverse reactions reported in multiple dose, placebo-controlled clinical studies involving 264 patients with spasticity were dry mouth, somnolence /sedation, asthenia (weakness, fatigue and/or tiredness) and dizziness. Mutagenesis Tizanidine was negative in in vitro (bacterial reverse mutation Ames, mammalian gene mutation, and chromosomal aberration test in mammalian cells) and in vivo ( bone marrow micronucleus, and cytogenetics ) assay. The CNS-depressant effects of tizanidine and alcohol are additive. Each time you have your prescription filled, look at the tablets zanaflex or capsules in the bottle and make sure that you have received the right product. Get emergency medical help if zanaflex you have signs of an allergic reaction : hives ; difficult breathing; swelling of your face, lips, tongue, or throat. You should take zanaflex this medicine zanaflex only for daily activities that require relief from muscle spasms. Cunha, DO, facoep; Board Certified Emergency Medicine. Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. Marketed and Distributed by: china Acorda Therapeutics Inc. . Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. However, you should not flush this medication down the toilet. Food also increased the extent of absorption for both zanaflex the tablets and capsules. If higher doses are required, individual doses rather than dosing frequency should be increased. Its chemical name is 5-chloro-4-(2- monohydrochloride. It is not recommended that Zanaflex be used with other 2- adrenergic agonists. Tell patients that Zanaflex may cause them to become sedated or somnolent and they should be careful when performing activities that require alertness, such as driving a vehicle or operating machinery. Taking china tizanidine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. 7 Contents Medical uses edit Tizanidine has been found to be as effective as other antispasmodic drugs and is more tolerable than baclofen and diazepam. If you experience a serious side effect, you or your doctor may send a report zanaflex to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( ) or by phone ( ). The primary cytochrome P450 isoenzyme involved in tizanidine metabolism is CYP1A2. Because the effect of Zanaflex peaks at approximately 1 to 2 hours post-dose and dissipates between 3 to 6 hours post-dose, treatment can be repeated at 6 to 8 hour intervals, as needed, to a maximum of three doses in 24 hours. The CNS depressant effects of Zanaflex with alcohol and other CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants ) may be additive. Remember that alcohol can add to the drowsiness china caused by this medication. What should I avoid while taking Zanaflex? Indications Dosage, low Back Pain Slideshow, take the Back Pain Quiz! Two studies were conducted in patients with multiple sclerosis and one in patients with spinal cord injury. Dry mouth, drowsiness, dizziness, lightheadedness, constipation, weakness, and tiredness may occur. Tell your doctor about all your current medicines and any you start or stop using, especially: acyclovir ; ticlopidine ; zileuton ; birth control pills; an antibiotic -ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, or ofloxacin ; blood pressure medicine - clonidine, guanfacine.

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